منابع مشابه
Actions of Steroids: New Neurotransmitters.
Over the past two decades, the classical understanding of steroid action has been updated to include rapid, membrane-initiated, neurotransmitter-like functions. While steroids were known to function on very short time spans to induce physiological and behavioral changes, the mechanisms by which these changes occur are now becoming more clear. In avian systems, rapid estradiol effects can be med...
متن کاملInhibitory effects of neurotransmitters and steroids on human CYP2A6.
Human CYP2A6 catalyzes the metabolism of nicotine, cotinine, and coumarin as well as some pharmaceutical drugs. CYP2A6 is highly expressed in liver and, also, in brain and steroid-related tissues. In this study, we investigated the inhibitory effects of neurotransmitters and steroid hormones on CYP2A6 activity. We found that coumarin 7-hydroxylation and cotinine 3'-hydroxylation by recombinant ...
متن کاملSlow actions of neuroactive steroids at GABAA receptors.
Neuroactive steroids are potent and efficacious modulators of GABA(A) receptor activity and are potent sedatives and anesthetics. These positive modulators of GABA(A) receptors both potentiate the actions of GABA at the receptor and, at higher concentrations, directly gate the channel. The contribution of direct gating to the cellular and behavioral effects of neuroactive steroids is considered...
متن کاملOverlapping nongenomic and genomic actions of thyroid hormone and steroids
The genomic actions of thyroid hormone and steroids depend upon primary interactions of the hormones with their specific nuclear receptor proteins. Formation of nuclear co-activator or co-repressor complexes involving the liganded receptors subsequently result in transcriptional events-either activation or suppression-at genes that are specific targets of thyroid hormone or steroids. Nongenomic...
متن کاملActions and uses of orally active progestational steroids.
25 November 1961 Eighty-fifth (Special General) Meeting PAGE Cameron, C. B. Oestrogen conjugates in the hepatic venous blood of the calf . . i Short, R. V. Further observations on defective synthesis of ovarian steroids in the SteinLevanthal syndrome ............ ii James, V. H. T. and Peart, W. S. Urinary steroid excretion in idiopathic hirsutism . ii Bush, I. E., Meigs, R. A. and Hunter, Shei...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2016
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2473-16.2016